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Montelukast is a selective, orally active leukotriene receptor antagonist that blocks the cysteinyl leukotriene receptor (CysLT1). Cysteinyl leukotrienes (LTC4, LTD4, LTE4), products of arachidonic acid metabolism, are released by cells such as mast cells and eosinophils. These leukotrienes are involved in the pathophysiology of asthma and allergic rhinitis, contributing to airway swelling, smooth muscle contraction, and other inflammatory processes that lead to asthma symptoms.
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✅ Description:
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✔️ Trilock is used for the following purposes:
- Prophylaxis and long-term management of asthma
- Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
- Relief of symptoms of Allergic Rhinitis (AR), including both seasonal and perennial forms
Use only as per the advice of a registered healthcare professional.
✔️ Side Effects
- Common: Diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory infections.
- Uncommon: Anxiety, dizziness, muscle pain, abnormal behavior, sleep disturbances.
- Rare: Severe allergic reactions (angioedema), hallucinations, suicidal tendencies, liver issues, memory loss, palpitations.
✔️ Overdose Effects:
Overdose may cause abdominal pain, drowsiness, headache, vomiting, and hyperactivity. Supportive measures, including removing unabsorbed material and clinical monitoring, are recommended.
✔️ Dosage & Administration:
- Adults and adolescents with asthma or seasonal allergic rhinitis: 10 mg tablet once daily for those aged 15.
- Pediatric patients with asthma or seasonal allergic rhinitis:
- 6 to 14 years: 5 mg tablet once daily.
- 2 to 5 years: 4 mg tablet once daily.
- 6 months to 5 years: 4 mg oral granules once daily (can be taken directly or mixed with cold water or soft food).
No dose adjustment is needed for patients with mild-to-moderate hepatic or renal insufficiency or the elderly.
✔️ Interactions:
Trilock is compatible with common asthma treatments like theophylline, prednisone, oral contraceptives, digoxin, and warfarin without significant drug interactions. However, potent cytochrome P450 enzyme inducers like phenobarbital may reduce Trilock's effectiveness, so monitoring is advised.
✔️ Contraindications:
Trilock should not be used in patients who are allergic to any of its components.
✔️ Pregnancy & Lactation:
Montelukast can cross the placenta in animals, but there are no sufficient studies in pregnant women. It should be used during pregnancy only if necessary. Since the drug is excreted in breast milk, caution should be exercised when breastfeeding.
✔️ Precautions & Warnings:
- Trilock is not for the immediate relief of acute asthma attacks. Patients should have appropriate rescue medication available.
- Trilock should not be substituted abruptly for corticosteroids in asthma management.
- Patients with aspirin sensitivity should avoid aspirin or NSAIDs while using Trilock.
✔️ Storage Conditions:
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
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accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
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